by Environmental Research Laboratory, Office of Research and Development, U. S. Environmental Protection Agency, Available to the public through the National Technical Information Service in Gulf Breeze, Fla, Springfield, Va .
Written in English
|Statement||by Robert S. Anderson|
|Series||Ecological research series -- EPA-600/3-78-009, Research reporting series -- EPA-600/3-78-009|
|Contributions||Environmental Research Laboratory (Gulf Breeze, Fla.)|
|The Physical Object|
|Pagination||v, 18 p. :|
|Number of Pages||18|
The sediment is acutely toxic and highly teratogenic to a variety of species of aquatic organisms including American oysters (Crassostrea virginica), brackish water clams Varanasi U, Nishimoto M, Reichert WL, Le Eberhart BT. Comparative metabolism of benzo(a)pyrene and covalent binding to hepatic DNA in English sole, starry flounder Cited by: Using a sensitive, radioisotopic assay for aryl hydrocarbon hydroxylase (AHH), a comparatively low level of benzo(a)pyrene (BaP) metabolism was routinely measured in digestive gland homogenates. Attempts to induce overall BaP metabolism by exposure to Aroclor , an inducer of mammalian AHH, were largely by: 5. The levels of these components and rates of microsomal benzo[a]pyrene (BP) metabolism were highest in the digestive gland, and were very similar between species. In M. edulis there was a suggested seasonal variation in BP metabolism but no population differences in this activity or in levels of other components. Digestive gland microsomal Cited by: High-performance liquid chromatographic analysis showed that P 1B1 catalyzed benzo[a]pyrene to trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene at level of ∼3 nmol min-1 nmol of P only when epoxide hydrolase was present and P 1A1 (with the hydrolase) was able to catalyze benzo[a]pyrene at one-tenth of the activity catalyzed by P 1B1.
Benzo[a]pyrene metabolism. Benzo[a]pyrene is a procarcinogen produced during incomplete combustion of organic compounds such as oil, gasoline and charbroiled food. The mechanism of carcinogenesis of Benzo[a]pyrene is defined by its enzymatic conversion to the ultimate mutagen, Benzo[a]pyrene diol epoxide (BPDE,).This molecule intercalates in DNA by forming covalent bond . Benzo[a]pyrene (B[a]P), a representative polycyclic aromatic hydrocarbon (PAH), is metabolically activated by three enzymatic pathways; by peroxidases (e.g. cytochrome Pperoxidase) to yield radical cations; by PA1/1B1 monoxygenation plus epoxide hydrolase to yield diol-epoxides; and by PA1/1B1 monoxygenation, epoxide hydrolase plus aldo-keto reductases (AKRs) to yield o Cited by: Fortner AR, Sick LV () Simultaneous accumulations of naphthalene, a PCB mixture, and benzo(a)pyrene, by the oyster, Crassostrea virginica. Bull Environ Contam Toxicol – Bull Environ Contam Toxicol –Cited by: I also acknowledge Dr. F. John Vernberg for his valuable guidance. This article is contribution number from the Belle W. Baruch Institute for Marine Biology and Coastal Ecology. References Anderson R. S. () Benzo(a)pyrene metabolism in the American oyster, Crassostrea by: 7.
Metabolism of a carcinogen by biralre molluscs TABLE 2 High-Performance Liquid Chromatography of `1C-BP Metabolites Produced by Bivalve Digestive Gland Homogenates (cpm, 45 min) Mercenaria mercenaria Crassostrea virginica Control Aroclor Aroclor Control Aroclor Aroclor (25Omg) ( mg) (25Omg)( mg) 9, l0-diol 48 4,5-diol Cited by: Request PDF | Transcriptomic evaluation of the American oyster, Crassostrea virginica, deployed during the Deepwater Horizon oil spill: Evidence of an active hydrocarbon response pathway. Bioremediation and microbial metabolism of benzo(a)pyrene. Erin M. Ostrem Loss. This review intends to compare what is known about bacterial and fungal degradation of toxic compounds using benzo(a)pyrene as a relevant example. Most research is done in the context of using fungi for bioremediation, however, we intend to also point out how Cited by: 6. Environmental Health Perspectives is an Open Access journal published by the National Institute of Environmental Health Sciences. The sediment is acutely toxic and highly teratogenic to a variety of species of aquatic organisms including American oysters (Crassostrea virginica), Comparative metabolism of benzo(a)pyrene and covalent Cited by: